Loss of GABA<sub>B</sub> receptor 1 signaling facilitates activation of disease‐associated microglia in the mouse model of Alzheimer’s disease

Our findings delineate a novel role of loss of the GABA<sub>B</sub>R1 signaling in AD-associated DAM activation, and elevating GABA<sub>B</sub>R1 activity within DAM holds promise for enhancing microglial structure and function, ultimately alleviating AD-like pathology and behavioral deficits in the mouse model of Alzheimer's disease.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.084480
Primary Topic
Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Loss of GABAB receptor 1 signaling facilitates activation of disease‐associated microglia in the mouse model of Alzheimer’s disease

Jiali Li
Alzheimer s & Dementia
Neurological Disorders and Treatments
article

Loss of GABAB receptor 1 signaling facilitates activation of disease‐associated microglia in the mouse model of Alzheimer’s disease

Jiali Li
article en

Abstract

Our findings delineate a novel role of loss of the GABA<sub>B</sub>R1 signaling in AD-associated DAM activation, and elevating GABA<sub>B</sub>R1 activity within DAM holds promise for enhancing microglial structure and function, ultimately alleviating AD-like pathology and behavioral deficits in the mouse model of Alzheimer's disease.

Alzheimer s & DementiaVol. 20(S1)
John F. Kennedy Medical Center (US)
Good health and well-being
Openalex Percentile: Top 71%
Neurological Disorders and Treatments
DOIOpen Access PDFOpenAlex
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Loss of GABA<sub>B</sub> receptor 1 signaling facilitates activation of disease‐associated microglia in the mouse model of Alzheimer’s disease — Jiali Li · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS