Alzheimer’s Disease patient stratification using iPSC‐derived hindbrain organoids as a novel pre‐clinical tool for drug testing
Highly reproducible, people-specific 5-HT-organoids were thus used to study inter-patient phenotypical variability and drug response diversity in a powerful, novel pre-clinical tool. References: [1] Kim CK et al (2022). J Alzheimers Dis. 2022;87(1):83-100. https://doi.org/10.3233/JAD-215699. [2] Lyketsos CG et al (2011). J. Alzheimers Assoc. 7(5):532-539. https://doi.org/10.1016/j.jalz.2011.05.2410 [3] Sagar R et al (2023). Cells. 12(15):1990. https://doi.org/10.3390/cells12151990.
Authors
- Vasiliki Machairaki
- Cristina Zivko (ORCID: https://orcid.org/0000-0002-4933-156X)
- Constantine G. Lyketsos (ORCID: https://orcid.org/0000-0003-3827-4720)
- Ram Sagar (ORCID: https://orcid.org/0000-0002-4297-2639)
- Ariadni Xydia (ORCID: https://orcid.org/0009-0003-6557-5497)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Bayview Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089065
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00