The <i>klotho</i> F/C AD risk haplotype drives distinct phenotypes in a novel mouse model
These data suggest the native mouse klotho allele may act similarly to the protective KL-V/S haplotype, while the KL-F/C haplotype leads to lower secreted klotho and potentially greater disease risk. These models are therefore suitable for experiments to elucidate how klotho variants protect from AD pathologies, and will enable detailed studies of how this protection is specific to the APOE4 genotype.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Dylan Garceau
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Christoph Preuß (ORCID: https://orcid.org/0000-0003-1039-6080)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Channing Weber
- Rafiou Agoro (ORCID: https://orcid.org/0000-0002-5461-7685)
Institutions
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090967
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 0.00