Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
TREM2 knockout was found to be associated with abnormalities in multiple metabolic pathways in AD mice, particularly lipid metabolism and glucose metabolism. Also, LPL is a novel gene that may affect lipid metabolism and sphingolipid metabolism in AD mice.
Authors
- Qi Qin (ORCID: https://orcid.org/0000-0002-3019-2061)
- Yi Tang
- Meng Wang (ORCID: https://orcid.org/0000-0002-4970-8590)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085147
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00