Propagation of distinct tau strains in neuronal systems with physiological tau expression

Our findings indicate that different tau strains manifest as dynamic entities, exhibiting variability not only in molecular conformations and structural arrangements but also in the kinetics of inter-neuronal propagation. This diversity might contribute to the observed heterogeneity in AD phenotypes. The presence of different tau strains among AD patients introduces an added layer of complexity to disease progression and outcomes. Consequently, it may be worthwhile to consider more personalized therapeutic interventions tailored to individual patients.