Vascular‐based risk scores for the prediction of Alzheimer’s disease pathology biomarkers and cognitive status in older adults at‐risk for dementia: Exploratory analysis of sex and ethno‐racial differences
Significant differences in distinct VDRSs were found in relation to brain amyloid pathology levels and clinico-cognitive status, with ethno-racial influences potentially contributing to noted differences. Risk composites accounting for these factors will be useful for greater precision around pre-selection of at-risk populations towards targeted trials for disease modifying therapies and optimal management of clinical care.
Authors
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Chinedu Udeh‐Momoh (ORCID: https://orcid.org/0000-0002-7357-4692)
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Kiran Kumar Solingapuram Sai (ORCID: https://orcid.org/0000-0002-6442-5169)
- James R. Bateman
- Tuğçe Duran (ORCID: https://orcid.org/0000-0002-3502-8295)
- Timothy M. Hughes (ORCID: https://orcid.org/0000-0002-2919-7199)
- Samuel N. Lockhart (ORCID: https://orcid.org/0000-0002-0893-5420)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
Institutions
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093316
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00