Validation Of the Tau Heterogeneity Evaluation in Alzheimer’s Disease (THETA) Score Using Longitudinal and Histopathology Data
THETA remained clearly negative or positive in MCI and AD, providing consistent information on underlying etiology of impairment at both baseline and follow-up. Although binary in its construction, THETA both provided separation of values based on tau status and its change correlated with baseline amyloid burden especially in discordant-CU where tau deposition is not in typical meta-ROIs. Further work is needed to confirm if THETA captures early tau changes.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Alejandro Costoya‐Sánchez (ORCID: https://orcid.org/0000-0002-5072-1282)
- Anthony J. Spychalla
- Jonathan Graff‐Radford
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Robel K Gebre (ORCID: https://orcid.org/0000-0002-5746-0994)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Sheelakumari Raghavan (ORCID: https://orcid.org/0000-0001-8652-7011)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Fiona Heeman
- Alexis Moscoso (ORCID: https://orcid.org/0000-0003-0170-036X)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Ronald C. Petersen
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
Institutions
- Mayo Clinic (US)
- Universidade de Santiago de Compostela (ES)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091770
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00