Transcriptome Signatures for Cognitive Resilience Among Individuals with Pathologically Confirmed Alzheimer Disease
We identified multiple DEGs for cognitive resilience, several of which were also associated with measures of cognitive performance prior to death and AD-related neuropathological traits at autopsy, thus providing important insights into resilience mechanisms and strategies for delaying clinical symptoms of AD. Notably, ADAMTS2 was the top-ranked DEG in a study conducted in brains from African American AD cases and controls (see Logue et al. abstract for this meeting).
Authors
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Gyungah Jun (ORCID: https://orcid.org/0000-0002-3230-8697)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Donghe Li (ORCID: https://orcid.org/0000-0001-6773-3143)
- Xudong Han (ORCID: https://orcid.org/0000-0001-7961-5179)
Institutions
- Boston University (US)
- VA Boston Healthcare System (US)
- Boston Public Schools (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090972
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65