Single‐cell spatial and non‐spatial RNA sequencing on herpes simplex virus 1 (HSV‐1) infected 2D and 3D cerebral organoids reveal molecular granularity on virus‐human gene interactions in Alzheimer’s disease
Taken together, our use of multi-transcriptomics technologies has enabled us to gain course to fine molecular granularity into neuroinflammation-induced AD viral-human gene interactions and a careful dissection of the multi-transcriptomics data enables us to gain insights into biomarkers and gene targets for AD therapeutics development in the near future.
Authors
- Yingleong Chan (ORCID: https://orcid.org/0000-0003-4474-6114)
- Khanh V. Tran (ORCID: https://orcid.org/0000-0002-0121-6212)
- Nathaniel Barton (ORCID: https://orcid.org/0000-0002-0383-7741)
- Benjamin Readhead
- Adrian R. Orszulak (ORCID: https://orcid.org/0000-0003-2358-5702)
- Meagan N. Olson (ORCID: https://orcid.org/0000-0003-3373-9488)
- Pepper Dawes
- David M. Knipe (ORCID: https://orcid.org/0000-0003-1554-6236)
- Elaine T. Lim (ORCID: https://orcid.org/0000-0003-3651-0654)
- Liam F. Murray
- Samantha M. Chigas (ORCID: https://orcid.org/0000-0003-1477-021X)
- George M. Church
- Hyungsuk Oh (ORCID: https://orcid.org/0000-0002-1213-9515)
- Jonathan Sundstrom
Institutions
- Harvard University (US)
- University of Massachusetts Chan Medical School (US)
- Arizona State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092866
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00