Unraveling the dysregulation of Frizzled receptors in Alzheimer’s disease: Critical contributor for synapse loss
Decreased phosphorylation and ubiquitination of β-catenin is observed in nine- month-old APP/PS1 mice compared to wild type suggesting an elevated Wnt signaling at the synapse. Our study provides novel insight into how elevated Wnt signaling could contribute to the synapse loss in AD.
Authors
- Reddy Peera Kommaddi (ORCID: https://orcid.org/0000-0002-5874-944X)
- Nimisha Basavaraju (ORCID: https://orcid.org/0009-0004-3110-6489)
Institutions
- Manipal Academy of Higher Education (IN)
- Indian Institute of Science Bangalore (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090214
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33