Longitudinal Neuropsychiatric Symptom Trajectories in Frontotemporal Dementia: From Presymptomatic to Symptomatic Conversion
This study suggests that people with familial FTD, particularly those predicted to have underlying TDP-43 pathology, may experience more severe neuropsychiatric symptoms like psychosis or hyperactivity as they progress from presymptomatic to prodromal phases. This trajectory appears distinct from those with tau pathology or sporadic FTD. Further studies are warranted to understand these unique progression patterns and their implications for FTD management.
Authors
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Maria I. Lapid (ORCID: https://orcid.org/0000-0002-1163-5584)
- Ian R. Mackenzie (ORCID: https://orcid.org/0000-0003-3875-2972)
- Ging‐Yuek Robin Hsiung (ORCID: https://orcid.org/0000-0002-8017-0856)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Howard J. Rosen (ORCID: https://orcid.org/0000-0001-9281-7402)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Katherine P. Rankin (ORCID: https://orcid.org/0000-0002-3611-0848)
- Hyun Woo Lee (ORCID: https://orcid.org/0000-0002-6879-9686)
- Atri Chatterjee (ORCID: https://orcid.org/0000-0002-9512-6292)
- Imogene Scott
- Adam L. Boxer
- Kejal Kantarci
Institutions
- Mayo Clinic (US)
- University of British Columbia (CA)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Brown University (US)
- WinnMed (US)
- University Memory and Aging Center (US)
- Occupational Cancer Research Centre (CA)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090036
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00