Neuropathological Mapping of Synaptic Vesicle Protein 2A in Human Brains: Ground Truth for PET Interpretation in Neurodegenerative Diseases

In conclusion, our findings demonstrate reduced SV2A density and protein levels in disease categories corresponding to specific regional vulnerabilities, corroborating SV2A as a reliable marker of brain tissue integrity. Nevertheless, the observed correlation between SV2A and synaptophysin changes was less robust than anticipated, prompting questioning into whether SV2A changes accurately reflect synaptophysin alterations. Additional studies comparing the utility of both markers in predicting clinical decline, metabolic shifts, and the progression of neurodegeneration are warranted.