TMEM106B C‐terminal fragments drive a distinct neurodegenerative proteinopathy in C<i>. elegans</i>.
Taken together, our data suggest expression of TMEM CT in C. elegans neurons provides a useful model for the functional characterization of TMEM106B proteinopathy in neurodegenerative disease. Comparison with other proteinopathy models will inform potential disease mechanisms.
Authors
- Ruben Riordan (ORCID: https://orcid.org/0000-0002-8124-3367)
- Brian C. Kraemer (ORCID: https://orcid.org/0000-0002-2252-7634)
Institutions
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088591
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00