Elucidating the phenotypic landscape of neurodegeneration using multiplexed single‐cell sequencing of defined neuronal co‐cultures <i>in vitro</i>

By enacting simple perturbations to cell-type composition and exposures in a neuronal model, we have modeled a subset of the phenotypes displayed in AD patients. This study can help elucidate the order of events of changes observed in AD, including those likely to directly induce neuronal cell death.