Inhibition of bone morphogenetic protein signaling prevents tau pathology
Evidence from mouse models and iPSC-derived human neurons strongly supports the hypothesis that increased BMP signaling is part of aging-related changes predisposing to tauopathies. Further, interactions between BMP signaling and genetic factors such as APOE4 act synergistically to increase tau phosphorylation and release. These observations suggest therapeutic interventions that reduce BMP signaling in the aging brain could potentially slow or prevent disease development.
Authors
- Amira Affaneh (ORCID: https://orcid.org/0000-0002-0149-3391)
- Anne K Linden (ORCID: https://orcid.org/0000-0002-9434-6103)
- John A. Kessler (ORCID: https://orcid.org/0000-0003-1948-7712)
- Chian‐Yu Peng (ORCID: https://orcid.org/0000-0003-3407-0894)
- Yung‐Hsu Tsai (ORCID: https://orcid.org/0000-0003-2605-769X)
- Elif Tunc‐Ozcan (ORCID: https://orcid.org/0000-0002-5112-3778)
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090468
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00