The role of clusterin and the variant rs11136000_T throughout the spectrum of Alzheimer’s disease

Our work shows significant correlation between CSF clusterin and the main AD biomarkers (PET and CSF) and synaptic proteins before disease onset, in subjects at high risk for the disease. In the later stage of the disease, clusterin protein and CLU mRNA levels are increased as a function of genotype and disease status, suggesting that CLU may play a protective role by increases in gene expression in the CNS.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.089488
Primary Topic
Clusterin in disease pathology
Type
article
Field-Weighted Citation Impact
0.00
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article

The role of clusterin and the variant rs11136000_T throughout the spectrum of Alzheimer’s disease

Marina Tedeschi Dauar, Judes Poirier, Anne Labonté, Cynthia Picard et al.
Alzheimer s & Dementia
Clusterin in disease pathology
article

The role of clusterin and the variant rs11136000_T throughout the spectrum of Alzheimer’s disease

Marina Tedeschi Dauar, Judes Poirier, Anne Labonté, Cynthia Picard, Sylvia Villeneuve
article en

Abstract

Our work shows significant correlation between CSF clusterin and the main AD biomarkers (PET and CSF) and synaptic proteins before disease onset, in subjects at high risk for the disease. In the later stage of the disease, clusterin protein and CLU mRNA levels are increased as a function of genotype and disease status, suggesting that CLU may play a protective role by increases in gene expression in the CNS.

Alzheimer s & DementiaVol. 20(S1)
Ministry of Education (BR), Douglas Mental Health University Institute (CA), Coordenação de Aperfeicoamento de Pessoal de Nível Superior (BR), McGill University (CA)
Good health and well-being
Openalex Percentile: Top 58%
Clusterin in disease pathology
DOIOpen Access PDFOpenAlex
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The role of clusterin and the variant rs11136000_T throughout the spectrum of Alzheimer’s disease — Marina Tedeschi Dauar, Judes Poirier, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS