Shift and night work in the fourth decade is associated with reduced brain volume in late life independent of amyloidogenic pathways: an Insight 46 study
Shift working in the early 30s is associated with lower brain volume in late-life independent of amyloidogenic pathways. While partially mediated by increased cardiovascular risk factors in night/shift workers, the majority of the effect is unexplained and may be a direct effect of night/shift working on brain health.
Authors
- Kirsty Lu (ORCID: https://orcid.org/0000-0002-8416-2183)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- Jonathan M. Schott (ORCID: https://orcid.org/0000-0003-2059-024X)
- Marcus Richards (ORCID: https://orcid.org/0000-0001-9191-2192)
- William Coath (ORCID: https://orcid.org/0000-0002-3976-9461)
- Sarah‐Naomi James (ORCID: https://orcid.org/0000-0002-3800-4416)
- T. M. Brown (ORCID: https://orcid.org/0000-0002-1793-9968)
- Jason D. Warren (ORCID: https://orcid.org/0000-0002-5405-0826)
- Josh King‐Robson (ORCID: https://orcid.org/0000-0002-3662-9404)
- Jo Barnes
- Jennifer Nicholas
Institutions
- London School of Hygiene & Tropical Medicine (GB)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092742
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00