Involvement of the choroid plexus in Alzheimer’s disease pathophysiology: A mouse and human proteomic study
ChP changes are associated with amyloid pathology. Key pathways involved in ChP dysfunction in AD are associated with the ECM, lysosomal function, lipids, protein processing, complement, vascular system and mitochondrion. The ChP could become a novel promising target for AD treatment.
Authors
- Johan Gobom (ORCID: https://orcid.org/0000-0001-6193-6193)
- Stephanie J. B. Vos (ORCID: https://orcid.org/0000-0002-2045-9818)
- Pieter Jelle Visser (ORCID: https://orcid.org/0000-0001-8008-9727)
- Betty Marije Tijms (ORCID: https://orcid.org/0000-0002-2612-1797)
- Roosmarijn E. Vandenbroucke (ORCID: https://orcid.org/0000-0002-8327-620X)
- Inez H.G.B. Ramakers (ORCID: https://orcid.org/0000-0002-4747-2879)
- Marlies Burgelman (ORCID: https://orcid.org/0000-0001-6610-6885)
- Clint De Nolf (ORCID: https://orcid.org/0000-0002-2033-1830)
- Aurore Delvenne (ORCID: https://orcid.org/0000-0001-8724-3010)
- Suzanne E. Schindler (ORCID: https://orcid.org/0000-0002-1680-1465)
- Charysse Vandendriessche (ORCID: https://orcid.org/0000-0002-8645-6396)
- Pieter Dujardin (ORCID: https://orcid.org/0000-0002-4678-0722)
- Frans R.J. Verhey
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- Washington University in St. Louis (US)
- Sahlgrenska University Hospital (SE)
- Ghent University Hospital (BE)
- Ghent University (BE)
- Maastricht University (NL)
- Amsterdam Neuroscience (NL)
- Prevent Alzheimer’s Disease 2020 (US)
- VIB-UGent Center for Inflammation Research (BE)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090722
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00