Tau ablation rescues vascular amyloid‐related deficits in a cerebral amyloid angiopathy model
We are currently evaluating the pathways observed in the distinct inflammatory profile in microglia and oligodendrocytes. Our results suggest that tau ablation decreased CAA pathology in the Tg-FDD mice model, which shows the potential therapeutic implications of targeting tau in CAA and related neurodegenerative diseases.
Authors
- Nur Jury (ORCID: https://orcid.org/0000-0002-1143-3595)
- Abigail Perkins (ORCID: https://orcid.org/0000-0001-7562-1635)
- Muriel D. Mardones (ORCID: https://orcid.org/0000-0002-6782-2776)
- Cristian A Lasagna Reeves
- Henika Patel (ORCID: https://orcid.org/0000-0002-2654-4669)
- Rubén Vidal (ORCID: https://orcid.org/0000-0002-5803-3871)
- Yamil Marambio
- Eduardo Juárez (ORCID: https://orcid.org/0000-0002-6096-1511)
- Jonathan O. Martinez (ORCID: https://orcid.org/0000-0002-0517-366X)
- Katie Vanderbosch
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092412
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00