A Common Epitope in p53 and Tau Protein Aggregates
The common epitope recognised by the p53 and tau antibodies suggests that this is a potential target for antibody therapy, as the ability to prevent the formation of the co-aggregates may permit p53 to continue its role as the 'guardian of the genome', a role which, if inhibited, could be a contributing factor to AD.
Authors
- David R. Lynch (ORCID: https://orcid.org/0000-0001-7168-214X)
- Rakez Kayed (ORCID: https://orcid.org/0000-0001-6216-8640)
- Nemil Bhatt (ORCID: https://orcid.org/0000-0001-5017-7312)
- Phanourios Tamamis (ORCID: https://orcid.org/0000-0002-3342-2651)
- Madeline Demny (ORCID: https://orcid.org/0009-0001-6363-5201)
- Madison Samples
Institutions
- The University of Texas Medical Branch at Galveston (US)
- Texas A&M University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087744
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00