Genomic landscape of RNA editing and genome regulatory signatures in aged human brains with Alzheimer’s disease
Our study offers brain-wide region-specific and common RNA editing signatures in AD. This underlying altered landscape of RNA-editing and cis-edQTLs may account for the genetic etiology and pathobiology of AD and other neurodegenerative diseases.
Authors
- Feixiong Cheng (ORCID: https://orcid.org/0000-0002-1736-2847)
- Yayan Feng (ORCID: https://orcid.org/0000-0002-3932-0779)
- Amit Kumar Gupta (ORCID: https://orcid.org/0000-0002-9829-2974)
- William Robert Martin (ORCID: https://orcid.org/0000-0003-0616-0462)
Institutions
- Cleveland Clinic (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089503
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00