Domain Specific Age at Onset of Decline in Down Syndrome
AD decline occurs at the age of 54 and is preceded by a change in cognition and memory ∼4 years earlier. Sex does not affect decline onset. Change in memory and cognition are closely related while behavioral/emotional changes are not strongly associated with AD-related decline or other domains.
Authors
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- James Tyler Kennedy
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089191
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00