Cross‐species protein interactome network‐based analysis of GWAS and human brain quantitative trait loci (x‐QTL) data identifies risk genes and drug targets for Alzheimer’s disease
In summary, we presented a cross-species protein interactome network methodology that utilizes functional genomic and GWAS findings to identify disease risk genes and drug targets for AD and other neurodegenerative diseases if broadly applied. Functional observations of candidate targets and genes are warranted in the future.
Authors
- Feixiong Cheng (ORCID: https://orcid.org/0000-0002-1736-2847)
- James B. Leverenz (ORCID: https://orcid.org/0000-0002-0896-0749)
- Andrew A. Pieper (ORCID: https://orcid.org/0000-0001-6299-6577)
- Yadi Zhou (ORCID: https://orcid.org/0000-0002-6049-0545)
- Jielin Xu
- Yuan Hou
Institutions
- Cleveland Clinic (US)
- University Hospitals of Cleveland (US)
- Lou Ruvo Brain Institute (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092617
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00