Shared and Distinct Epigenetic Profiles in Primary Age‐Related Tauopathy and Alzheimer’s Disease: Insights into Tangle Formation and Spread
DNA methylation distinguishes PART and AD brain. We identify tau-specific DMPs that account for variance in NFT burden among aging individuals, both in the absence and presence of amyloid plaques in PART and AD, respectively. In PART, tau-DMPs are fully orthogonal to the set of amyloid-DMPs. In contrast, in AD, the tau-DMPs have both amyloid-associated and amyloid-independent subsets with separate gene enrichment profiles. Therefore, distinct epigenetic events may drive pathology within the limbic system compared to those that drive tau spread to neocortex.
Authors
- Anil R. Wadhwani (ORCID: https://orcid.org/0000-0002-7007-2371)
- Wanding Zhou (ORCID: https://orcid.org/0000-0001-9126-1932)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Kurt W. Farrell (ORCID: https://orcid.org/0000-0001-6955-7278)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- David Bennett (ORCID: https://orcid.org/0000-0001-5354-152X)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Eddie B Lee
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- Part Working Group
- David Goldberg
Institutions
- Rush University Medical Center (US)
- Children's Hospital of Philadelphia (US)
- Columbia University Irving Medical Center (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092601
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00