Sex‐stratified GWAS for Alzheimer’s Disease Reveals African Ancestry Risk variants in Men

The study is an initial exploration of sex-specific genetic effects in African ancestry individuals and warrants replication in larger data. Importantly, we show the relevance of expanding beyond non-Hispanic white samples for sex dimorphism research, identifying male-specific risk variants that have elevated frequencies in African ancestry, while being rare in other ancestries. In ongoing work, we are performing cross-ancestry meta-analyses of sex-stratified GWAS followed by sex-stratified omics integration to increase power to uncover sex-specific genes relevant to AD.