Heart rate and electrodermal activity during key driving events in older adult drivers with and without elevated amyloid burden

Amyloid positive older drivers exhibited relatively elevated HR responses while driving in more complex situations (at stop signs or heavier traffic). This pattern of driving behavior and accompanying physiological responses that account for participants' individual variability may indicate an early sign of cognitive change in older individuals with high amyloid burden. These attributes can be used as effective features to build a Machine Learning-based AD diagnosis tool to detect early-stage AD in older drivers.