Cortical and ventricular brain retention of <sup>11</sup>C‐PIB assessed by dynamic PET/CT and correlation with the Aβ1‐42/Aβ1‐40 ratio of amyloid peptides in the cerebral spinal fluid. Preliminary analysis in a healthy control volunteer population
In our control healthy population, there is a correlation between the dynamic parameters of cerebral clearance of <sup>11C</sup>-PIB and the CSF amyloid value, with differences between subjects with a pathological and normal CSF amyloid values. Larger studies are necessary to determine the value of these findings in the preclinical Alzheimer's disease.
Authors
- Francisco Javier Gómez de la Fuente
- R. Quirce
- Virginia Mendi-Barcina
- M. de Arcocha-Torres
- J. Jiménez‐Bonilla
- Francisco Martínez‐Dubarbie (ORCID: https://orcid.org/0000-0002-1482-7813)
- Sara López‐García (ORCID: https://orcid.org/0000-0002-7888-8850)
- Carmen Lage (ORCID: https://orcid.org/0000-0003-1703-121X)
Institutions
- Universidad de Cantabria (ES)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089223
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00