Tracing senescence in the Alzheimer’s brain through an eigengene‐based analysis of snRNA‐Seq data

Our findings validate a computational strategy for detecting senescent cells via eigengene analysis. Consistent identification of senescent cell signatures between inferred and recalculated eigengenes across neural and vascular cells confirms the accuracy of our methods. This approach may direct AD therapeutic development by pinpointing precise senescent cell targets, and uncover new biomarkers of brain cell senescence.