Alzheimer’s disease‐associated gut microbes shape neuroinflammatory tone and disease outcomes in mouse models
Together, these results highlight the neuroimmune modulatory potential of AD-associated gut bacteria. In particular, the present study demonstrates how increased intestinal exposure to non-pathogenic E. coli is sufficient to modify neuroinflammatory tone, cognition, and pathology in 5xFAD mice, highlighting the potential importance of this microbe for AD.
Authors
- Jianjun Chang (ORCID: https://orcid.org/0000-0001-6707-1944)
- Adam M. Hamilton (ORCID: https://orcid.org/0000-0002-8857-3617)
- Steven A. Sloan (ORCID: https://orcid.org/0000-0001-7769-7684)
- A. V. Kozlov (ORCID: https://orcid.org/0000-0001-9384-6854)
- Timothy R. Sampson (ORCID: https://orcid.org/0000-0002-2486-8766)
- Maureen M. Sampson (ORCID: https://orcid.org/0000-0003-1536-3229)
- Sean D. Kelly (ORCID: https://orcid.org/0000-0001-6625-5258)
- Lisa Blackmer‐Raynolds (ORCID: https://orcid.org/0000-0001-5436-174X)
- Andrew Yang (ORCID: https://orcid.org/0000-0002-1635-4036)
- Lyndsey D. Lipson
Institutions
- Emory University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087048
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.23