Automated image segmentation uncovers the association of a microglial subtype defined by High CD74 Expression with cognitive decline
We report a potential role of CD74<sup>high</sup> microglial cells in cognitive decline and present evidence that they have a morphologic characteristic that is shared with stage III microglia. Thus, we have used a new automated image segmentation pipeline optimized for the characterization of microglia to define and explore the functional characteristics and topological features of a microglial subtype associated with AD that was originally defined using single cell transcriptomic profiles.
Authors
- Masashi Fujita (ORCID: https://orcid.org/0000-0002-1457-6233)
- Mariko Taga (ORCID: https://orcid.org/0000-0003-3780-7054)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Neelang Parghi (ORCID: https://orcid.org/0000-0001-7130-2805)
Institutions
- NewYork–Presbyterian Hospital (US)
- Columbia University Irving Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092664
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25