Genotype specific microbiome divergence of humanized APOE 2, 3, and 4 mice after microbiome standardization
These are the first data demonstrating GMB divergence over time driven by APOE genotype. Studying genotype specific changes in GMB and how specific APOE-specific bacteria impact inflammatory responses can aid in understanding and potentially treating some of the underlining diseases associated ApoE 4 allele including cardiovascular disease and Alzheimer's Disease (AD).
Authors
- Tiffany Hensley‐McBain (ORCID: https://orcid.org/0000-0001-6753-5622)
- Makayla Cook
- Michelle L. Aries (ORCID: https://orcid.org/0000-0003-3398-3958)
- Anna Perez (ORCID: https://orcid.org/0000-0002-8488-3300)
- Hope Gasvoda
- Ashley Gooman
Institutions
- University of Providence (US)
- Providence College (US)
- Touro College (US)
- Great Falls Clinic (US)
- McLaughlin Research Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089264
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00