Sex‐specific genetic regulation of proteomics in cerebrospinal fluid uncovers genetic causes for sex differences in neurodegeneration
By performing sex-stratified pQTL, we uncovered distinctive sex-specific genetic regulation of CSF proteome. Our findings complement sex-aware eQTL from GTEx and provide insights on dissecting the underlying biological causes and mechanisms contributing to sex differences in neurodegeneration.
Authors
- Han Chen (ORCID: https://orcid.org/0000-0002-9510-4923)
- Agustı́n Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Daniel Western (ORCID: https://orcid.org/0000-0003-3725-9553)
- Pau Pástor (ORCID: https://orcid.org/0000-0002-7493-8777)
- Carlos Cruchaga (ORCID: https://orcid.org/0000-0002-5261-689X)
- Lihua Wang (ORCID: https://orcid.org/0000-0002-0125-1544)
- Yun Ju Sung (ORCID: https://orcid.org/0000-0002-8021-4070)
- Priyanka Gorijala (ORCID: https://orcid.org/0000-0001-7109-7362)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
Institutions
- Washington University in St. Louis (US)
- Fundació ACE (ES)
- Mútua Terrassa (ES)
- NeoGenomics (United States) (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089696
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00