Decreased practice effects in preclinical Alzheimer’s disease: a multicenter, longitudinal, cohort study
Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over serial neuropsychological testing. Our findings suggest the reduction of practice effects, particularly in memory measures, as an indicator of subtle cognitive decline in the earliest phase of the Alzheimer's continuum and could be particularly relevant for the design and interpretation of primary prevention trials on disease-modifying therapies.
Authors
- Sara Rubio‐Guerra (ORCID: https://orcid.org/0000-0001-7652-8029)
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Mirian Ecay‐Torres (ORCID: https://orcid.org/0000-0001-7170-6180)
- Alberto Lleó (ORCID: https://orcid.org/0000-0002-2568-5478)
- Ana Pozueta
- Ainara Estanga (ORCID: https://orcid.org/0000-0002-6616-314X)
- María Araceli García Martínez
- Agnès Pérez‐Millan (ORCID: https://orcid.org/0000-0002-3006-9792)
- Núria Guillén (ORCID: https://orcid.org/0000-0002-1341-9834)
- Albert Lladó (ORCID: https://orcid.org/0000-0002-5066-4150)
- Eloy Rodríguez‐Rodríguez (ORCID: https://orcid.org/0000-0001-7742-677X)
- Jordi Sarto (ORCID: https://orcid.org/0000-0002-6030-3375)
- Lorena Rami (ORCID: https://orcid.org/0000-0002-7411-1921)
- Bea Bosch
- Jordi Juncà‐Parella (ORCID: https://orcid.org/0000-0002-4772-2647)
- Mircea Balasa (ORCID: https://orcid.org/0000-0002-1795-4228)
- Miren Altuna (ORCID: https://orcid.org/0000-0001-9709-5314)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Adrià Tort‐Merino (ORCID: https://orcid.org/0000-0002-5646-0482)
- Ignacio Illán‐Gala (ORCID: https://orcid.org/0000-0002-5418-2052)
- Pablo Martínez‐Lage
- Sergi Borrego‐Écija (ORCID: https://orcid.org/0000-0003-2557-0010)
- Nuole Zhu (ORCID: https://orcid.org/0000-0002-0015-9455)
- Pascual Sánchez‐Juan
- Diana Esteller (ORCID: https://orcid.org/0000-0003-0975-3052)
- Guadalupe Fernández‐Villullas (ORCID: https://orcid.org/0000-0002-0569-1344)
- Mikel Tainta (ORCID: https://orcid.org/0000-0003-0624-1211)
- Andrea Val‐Guardiola
- Magdalena Castellví (ORCID: https://orcid.org/0000-0001-8769-9288)
- Carolina López
- Neus Falgàs Martínez
- Anna Antonell
- Ma Belén Sánchez‐Saudinós
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universidad de Cantabria (ES)
- Universidad de Deusto (ES)
- Hospital de Sant Pau (ES)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Osakidetza (ES)
- Fundacion CITA Alzheimer (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Institut de Recerca Sant Pau (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087332
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00