Association between self‐reported SCD‐<i>plus</i> criteria and Alzheimer’s disease biomarkers in cognitively unimpaired older adults: meta‐analyses
Our results suggest that widespread endorsement of multiple SCD features is more powerful than a single criterion alone in identifying both Aβ and tau in CU older adults. We found that the isolated SCD criterion was particularly sensitive to elevated Aβ, even after adjustment for tau, supporting the power of SCD as a very early behavioral marker of preclinical AD.
Authors
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Gaël Chételat (ORCID: https://orcid.org/0000-0002-4889-7932)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Lorena Rami (ORCID: https://orcid.org/0000-0002-7411-1921)
- Elizabeth Kuhn (ORCID: https://orcid.org/0000-0002-3744-1155)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Carol A. Van Hulle (ORCID: https://orcid.org/0000-0002-2288-8819)
- Elke Butterbrod
- Michael Wagner (ORCID: https://orcid.org/0000-0003-2589-6440)
- Jarith L. Ebenau (ORCID: https://orcid.org/0000-0001-5447-7224)
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Dorene M. Rentz (ORCID: https://orcid.org/0000-0002-6318-9213)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Hannah M Klinger
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Frank Jessen
Institutions
- Brigham and Women's Hospital (US)
- University of Bonn (DE)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Inserm (FR)
- The University of Melbourne (AU)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- Instituto de Salud Carlos III (ES)
- German Center for Neurodegenerative Diseases (DE)
- Massachusetts General Hospital (US)
- Normandie Université (FR)
- Amsterdam Neuroscience (NL)
- Hospital Clínic de Barcelona (ES)
- Barcelonaβeta Brain Research Center (ES)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Amsterdam University Medical Centers (NL)
- Cyceron (FR)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Physiopathologie et imagerie des troubles neurologiques
- Universitat de Barcelona (ES)
- Vrije Universiteit Amsterdam (NL)
- Vanderbilt University Medical Center (US)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088662
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00