Fecal microbiome transplantation from stroke donors promotes Alzheimer’s disease brain pathology and hypoperfusion in the 3xTg‐AD mice
Our study provides evidence that gut dysbiosis following a stroke may actively contribute to the development of AD pathology and decrease CBF, thereby increasing the risk of AD. Addressing gut dysbiosis through dietary changes or medication could be crucial in helping stroke survivors reduce their risk of developing AD. These findings could pave the way for novel treatments aimed at lowering the risk of stroke-associated AD.
Authors
- Amitai Zuckerman
- Lixin Ma (ORCID: https://orcid.org/0000-0003-2171-1226)
- Ai‐Ling Lin (ORCID: https://orcid.org/0000-0002-5197-2219)
- Aaron C. Ericsson (ORCID: https://orcid.org/0000-0002-3053-7269)
- Chetan Aware
- Abeoseh Flemister
- Ya‐Hsuan Chang (ORCID: https://orcid.org/0000-0002-0743-4819)
- Jiankun Cui (ORCID: https://orcid.org/0000-0003-1147-0203)
- Zezong Gu
Institutions
- University of Kentucky (US)
- University of Missouri (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092891
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00