Temporal Progression of Pathophysiological Changes in hAPP‐J20 Transgenic Alzheimer’s Mice: Insights from Longitudinal Analysis

This study outlines the progression of pathophysiological changes in the AD mouse model, linking amyloid plaque deposition to seizure activity, NPY levels, neuronal cell density changes, and increased neural network excitability. The rise in HFO rates, especially fast ripples, suggests their potential as biomarkers for seizure onset or epileptogenesis, linking amyloid pathology with seizure pathology. These findings provide crucial insights for the development and timing of therapeutic strategies in AD.