Single vascular insult aggravates amyloid accumulation with age triggering glial activation in AD mice
APP mutation increases susceptibility to ET-1 induced single vascular insult bringing about BBB leakage, memory deficits, increased Aβ aggregation and glial activation with increasing age given enough time of 30 days to rescue. However, there was rescue in case of wild type mice.
Authors
- Ankita Talukdar
- Rehab Hussain
- Mayank Gupta (ORCID: https://orcid.org/0000-0002-9377-7403)
- Latha Diwakar (ORCID: https://orcid.org/0000-0003-0515-2428)
Institutions
- Manipal Academy of Higher Education (IN)
- Indian Institute of Science Bangalore (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092235
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00