Unravelling the mechanisms of aducanumab on efficacy of Aß clearance by iPSC‐derived human microglia in 2D and 3D cell cultures
Aducanumab acutely increases the ability of iPSC-derived microglia to phagocytose Aß and may also prevent Aß aggregation. 3D neurospheres can be used to study more functional impacts of aducanumab on neuronal function. Further analysis of phagocytosed Aß using biochemical techniques after anti-Aß antibody treatment will help to determine the precise molecular mechanisms of its effects.
Authors
- Haakon B. Nygaard (ORCID: https://orcid.org/0000-0001-5085-4723)
- Declan Brennan
- Stefan Wendt (ORCID: https://orcid.org/0000-0002-8754-2464)
- Ada J. Lin
Institutions
- University of British Columbia (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091108
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00