Computational Docking Analysis of APOE‐TREM2 Crosstalk with Therapeutic implications in Alzheimer’s disease (AD)
Computational docking analysis suggests that, TREM2 exhibited highest docking scores than R47H TREM2 which signify the latter's role in increasing AD risk. Interestingly, both TREM2 and R47H TREM2 exhibited highest docking scores against APOE 4 in comparison with APOE 2. Our computational docking analysis has therapeutic implications in AD which requires further experimental verification.
Authors
- M. Janaki Ramaiah (ORCID: https://orcid.org/0000-0003-1814-2819)
- Conner Sk
Institutions
- Koneru Lakshmaiah Education Foundation (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084634
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25