Cognitive resilience to Alzheimer’s disease characterized by cell‐type abundance estimates
High abundance of PVALB+ neurons and lack of astrocytosis may be markers of cognitive resilience among persons with a pathological diagnosis of AD. Variants in TMEM106B are associated with neuron abundance and, hence, may specifically influence resilience to cognitive decline independent of AD pathology.
Authors
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-8237-1857)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Oluwatosin A Olayinka
- Tong Tong (ORCID: https://orcid.org/0000-0002-4731-9807)
- Nicholas K. O’Neill (ORCID: https://orcid.org/0000-0002-9953-9940)
- Jenny A Empawi
- Junming Hu (ORCID: https://orcid.org/0000-0002-6503-7491)
Institutions
- Boston University (US)
- VA Boston Healthcare System (US)
- VA New England Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091390
- Primary Topic
- Machine Learning in Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 0.00