Subjective Cognitive Complaints: Heritability and Correlations with Dementia Diagnosis, Depression and Memory, Across Multiple Twin Studies
Consistent with our previous research, the heritability of SCC was low. The findings underscore the genetic connection between SCCs, objective memory performance, and depressive symptoms. The low heritability, however, suggests a substantial influence of environmental factors in explaining individual differences in SCC, highlighting the need for further research to better understand the dynamic influence of genetic and environmental influences on cognitive health.
Authors
- Anbupalam Thalamuthu (ORCID: https://orcid.org/0000-0002-7114-1260)
- Ashleigh S. Vella (ORCID: https://orcid.org/0000-0002-5653-5077)
- Vibeke S. Catts (ORCID: https://orcid.org/0000-0002-9892-0547)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- Amanda Selwood (ORCID: https://orcid.org/0000-0002-8286-4069)
- Katya T. Numbers (ORCID: https://orcid.org/0000-0002-7009-2401)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Chandra A. Reynolds (ORCID: https://orcid.org/0000-0001-6502-7173)
- Margaret Gatz (ORCID: https://orcid.org/0000-0002-1071-9970)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Ida Karlsson (ORCID: https://orcid.org/0000-0003-3605-7829)
- Teresa Lee (ORCID: https://orcid.org/0009-0002-9642-626X)
Institutions
- University of California, Riverside (US)
- University of Southern California (US)
- Karolinska Institutet (SE)
- UNSW Sydney (AU)
- University of California San Diego (US)
- Prince of Wales Hospital (AU)
- ARC Centre of Excellence in Synthetic Biology (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088371
- Primary Topic
- Cognitive Abilities and Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00