Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
We find evidence for some miRNAs being associated with AD-related traits and cognitive trajectory through age-related cerebral pathologies while other miRNAs are independently associated with AD-related outcomes. The miRNAs consistent with a causal role are promising candidates for future studies in model systems to understand how miRNAs contribute to AD and cognitive decline.
Authors
- Selina Vattathil (ORCID: https://orcid.org/0000-0001-5616-4184)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Aliza P. Wingo (ORCID: https://orcid.org/0000-0002-6360-6726)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
Institutions
- Rush University Medical Center (US)
- Emory University (US)
- Atlanta VA Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087046
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00