Tau‐induced astrocyte senescence and dysfunction in AD tauopathy
Our study showed that pathogenic tau is transmitted to cultured human astrocytes and that transmission of pathogenic tau to astrocytes triggers astrocyte senescence in a mouse model of AD tauopathy. Our data suggest that senescent astrocytes may be critical mediators of neuronal dysfunction in AD tauopathy.
Authors
- Haneen Makhlouf
Institutions
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093341
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65