Longitudinal cognitive trajectories in sporadic early‐onset Alzheimer’s Disease: Findings from LEADS
In addition to worse cognition at baseline, sporadic EOAD participants displayed pronounced declines in cognition over 24-56 months across all domains evaluated. Relative to the EOnonAD group, cognitive trajectories appear to be worse predominantly for executive and attentional processes, with variability across episodic memory tasks. This suggests that EOAD pathology is not solely directed at memory functioning. Future research will focus on comparing cognitive trajectories of EOAD and late-onset AD, in an effort to understand similarities and differences in the types and rates of cognitive trajectories.
Authors
- Alexander Taurone
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Bonnie Wong (ORCID: https://orcid.org/0000-0002-1449-6938)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Gil D. Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Bradford C. Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Maryanne Thangarajah
Institutions
- Alzheimer's Association (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Brown University (US)
- Massachusetts General Hospital (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092326
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39