Diminished learning rates in mnemonic discrimination of scenes but not objects are associated with beta‐amyloid positivity

The current results suggest that individuals with MCI show diminished learning rates in mnemonic discrimination of scenes, compared to CU individuals. We identified ceiling effects in the Object condition, which may have contributed to a null finding. Additionally, we found that Aβ positivity was associated with reduced learning of scenes but not objects, both in the overall sample and in individuals with no clinical indication of cognitive impairment. In conclusion, learning rates in the MDT-OS may be a sensitive marker of AD in individuals who do not yet meet the clinical threshold for cognitive impairment.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.089785
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Diminished learning rates in mnemonic discrimination of scenes but not objects are associated with beta‐amyloid positivity

David Berron, Sarah E. Polk, Helena M. Gellersen, Wenzel Glanz et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Diminished learning rates in mnemonic discrimination of scenes but not objects are associated with beta‐amyloid positivity

David Berron, Sarah E. Polk, Helena M. Gellersen, Wenzel Glanz, Yannik Lottes
article en

Abstract

The current results suggest that individuals with MCI show diminished learning rates in mnemonic discrimination of scenes, compared to CU individuals. We identified ceiling effects in the Object condition, which may have contributed to a null finding. Additionally, we found that Aβ positivity was associated with reduced learning of scenes but not objects, both in the overall sample and in individuals with no clinical indication of cognitive impairment. In conclusion, learning rates in the MDT-OS may be a sensitive marker of AD in individuals who do not yet meet the clinical threshold for cognitive impairment.

Alzheimer s & DementiaVol. 20(S3)
Lund University (SE), German Center for Neurodegenerative Diseases (DE), Otto-von-Guericke-Universität Magdeburg (DE)
Reduced inequalities
Openalex Percentile: Top 66%
Dementia and Cognitive Impairment Research
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Diminished learning rates in mnemonic discrimination of scenes but not objects are associated with beta‐amyloid positivity — David Berron, Sarah E. Polk, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS