Diminished learning rates in mnemonic discrimination of scenes but not objects are associated with beta‐amyloid positivity
The current results suggest that individuals with MCI show diminished learning rates in mnemonic discrimination of scenes, compared to CU individuals. We identified ceiling effects in the Object condition, which may have contributed to a null finding. Additionally, we found that Aβ positivity was associated with reduced learning of scenes but not objects, both in the overall sample and in individuals with no clinical indication of cognitive impairment. In conclusion, learning rates in the MDT-OS may be a sensitive marker of AD in individuals who do not yet meet the clinical threshold for cognitive impairment.
Authors
- David Berron (ORCID: https://orcid.org/0000-0003-1558-1883)
- Sarah E. Polk (ORCID: https://orcid.org/0000-0002-3862-8333)
- Helena M. Gellersen (ORCID: https://orcid.org/0000-0001-7544-2311)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Yannik Lottes
Institutions
- Lund University (SE)
- German Center for Neurodegenerative Diseases (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089785
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00