Midlife Neuroinflammatory Dynamics: The Emergence of Alzheimer’s Disease Neuroimmune Profile in the Female Human Brain

This comprehensive characterization provides compelling evidence of sex differences in neuroinflammation emerging during midlife. Notably, the midlife female brain exhibits a profile reminiscent of the inflammatory signature observed in the AD brain. The study presents an opportunity to identify distinct profiles emerging decades before AD diagnosis, and to inform precision medicine interventions that can be implemented to prevent or delay a key driver of AD pathology.