A systems‐biology approach to identify candidate genes associated with composite brain pathology scores in the Adult Changes of Thought (ACT) and the Religious Orders Study and Memory and Aging Project (ROSMAP) autopsy cohorts
We identified two potentially useful candidate loci associated with BPS using a systems-biology approach. Further functional enrichment analysis is needed to determine whether these novel loci may identify targets for interventions to ameliorate AD.
Authors
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Yuriko Katsumata (ORCID: https://orcid.org/0000-0002-0188-8094)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Lincoln M. P. Shade (ORCID: https://orcid.org/0000-0001-6093-4823)
- Caitlin S. Latimer (ORCID: https://orcid.org/0000-0003-3727-4278)
- Laura E. Gibbons (ORCID: https://orcid.org/0000-0001-5054-2543)
- Kyle J. Travaglini (ORCID: https://orcid.org/0000-0003-3164-6448)
- Mariano I. Gabitto (ORCID: https://orcid.org/0000-0001-6911-344X)
- Arkajyoti Dutta (ORCID: https://orcid.org/0000-0002-4251-9332)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Zijie Zhao (ORCID: https://orcid.org/0000-0001-6502-5821)
- Qiongshi Lu (ORCID: https://orcid.org/0000-0002-4514-0969)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0002-9093-539X)
- David W. Fardo (ORCID: https://orcid.org/0000-0002-7207-4696)
- Jai Broome (ORCID: https://orcid.org/0000-0001-7638-0749)
- Sagnik Sinha
Institutions
- Rush University Medical Center (US)
- Allen Institute for Brain Science (US)
- University of Wisconsin–Madison (US)
- University of Kentucky (US)
- University of Washington (US)
- Allen Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093129
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00