A multiethnic transcriptome for Alzheimer Disease identifies cross‐ancestry and ancestry‐specific expression profiles
To our knowledge, this is the largest diverse transcriptome study for AD in post-mortem tissue. We identified perturbated genes and pathways resulting in cross-ethnic and ethnic-specific findings, ultimately highlighting the importance of diversity in AD investigations.
Authors
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Lee‐Way Jin (ORCID: https://orcid.org/0000-0001-9729-1032)
- Brittany N. Dugger (ORCID: https://orcid.org/0000-0003-2141-8855)
- Basilio Cieza
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Tatiana Foroud
- Zikun Yang (ORCID: https://orcid.org/0000-0002-8834-6377)
- Andrew F. Teich (ORCID: https://orcid.org/0000-0002-1916-8490)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Margaret A Pericak‐Vance
Institutions
- Columbia University Irving Medical Center (US)
- WinnMed (US)
- Dr. John T. Macdonald Foundation (US)
- Mayo Clinic in Florida (US)
- University of California Davis Medical Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092011
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00