Regional microglial activation differs across the cortex of patients in the Alzheimer’s disease trajectory: A cross‐sectional study
The contrasting effects of reactive microglia on different pathological processes show regional disparities, with deleterious effects more closely associated with regions affected in the early stages of AD. This suggests a diverging response driven by both anti- and pro-inflammatory reactivity profiles. The former, neuroprotective, would emerge locally alongside early pathology, while the later, neurotoxic, would only appear with more advanced pathology. Consequently, potential treatments should promote anti-inflammatory polarization and supress pro-inflammatory activation in microglia for an effective therapeutic strategy.
Authors
- Rainer Hinz (ORCID: https://orcid.org/0000-0002-7808-9207)
- Harry Crook (ORCID: https://orcid.org/0000-0002-6206-470X)
- Paul Edison
- David J. Brooks (ORCID: https://orcid.org/0000-0003-2602-2518)
- Grazia Daniela Femminella (ORCID: https://orcid.org/0000-0002-7397-483X)
- Steve Gentleman (ORCID: https://orcid.org/0000-0002-7131-4643)
- Valeria Calsolaro (ORCID: https://orcid.org/0000-0001-6446-5251)
- Javier Alegre‐Abarrategui
- Christopher Dominic Buckley (ORCID: https://orcid.org/0000-0001-6924-6402)
- William Trigg (ORCID: https://orcid.org/0000-0003-4046-0813)
- Giuseppe Pasqualetti
- Marie Emilie Tuil
- Simona Jogaudaite
Institutions
- University of Manchester (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092255
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00