Connection between APOE4 and tau is mediated via amyloid‐beta and Alzheimer’s co‐pathologies in human autopsy brains
Our study suggests that APOE ε4 primary influence on pathological Tau is likely mediated through associations with Aβ, capillary CAA, and amygdala-predominant αSyn. Similar conclusions might hold for APOE ε4 and p-TDP-43, although further confirmation with a larger sample size is needed. Despite indications from animal models, our results suggest that the impact of APOE ε4 on pTau in the human brain may be minimal, linked to its high interconnection with other brain pathologies.
Authors
- Estifanos Ghebremedhin
- Alicja Ronisz (ORCID: https://orcid.org/0000-0002-4310-0445)
- Philip Van Damme (ORCID: https://orcid.org/0000-0002-4010-2357)
- Klara Gawor (ORCID: https://orcid.org/0000-0001-7571-5420)
- Kristel Sleegers (ORCID: https://orcid.org/0000-0002-0283-2332)
- Dietmar Rudolf Thal (ORCID: https://orcid.org/0000-0002-1036-1075)
- Simona Ospitalieri
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Sandra O. Tomé (ORCID: https://orcid.org/0000-0001-5253-0730)
- Mathieu Vandenbulcke (ORCID: https://orcid.org/0000-0001-9765-1499)
- Matthew B. Blaschko (ORCID: https://orcid.org/0000-0002-2640-181X)
- Celeste Laureyssen (ORCID: https://orcid.org/0000-0002-7373-2099)
- Christina von Arnim
- Jasper Van Dongen
- Sam Verrept
Institutions
- Goethe University Frankfurt (DE)
- University of Antwerp (BE)
- Universität Ulm (DE)
- Universitair Ziekenhuis Leuven (BE)
- Universitätsmedizin Göttingen (DE)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University Hospital Ulm (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086811
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00